Erectile dysfunction treatment has come a long way following the “hard-hitting” success of Viagra sildenafil following its launch in 1998. The blue pill enjoyed a monopoly in the market for about 5 years until Cialis tadalafil hit the market in 2003. The long search for an impotence pill that can give more time for sex finally came to an end with the discovery of a chemical compound called IC351 aka tadalafil. Unlike the chance discovery of sildenafil citrate, this compound had been well under clinical research from 1993, thanks to the joint initiative of Eli Lilly and ICOS. As a matter of fact, tadalafil was discovered before sildenafil as having inhibitory effects on the phosphodiesterase type-5 (PDE-5) enzyme. It was only because of the delay in clinical trials that prevented Cialis from appearing on the commercial drug market ahead of Viagra.
Initiation of clinical trials
In 1994, ICOS got the patent rights to go ahead with further research on IC351. Phase-I clinical trial started the next year, followed by the study of tadalafil on men with erectile dysfunction in 1997. The next year witnessed a merger between Eli Lilly and ICOS, which was a great news for the researchers who put in so much hard work to find a compound similar to UK-92480 (sildenafil citrate). The merger helped a lot in commercializing the drug and taking it from labs to pharmacies.
Birth of the brand ‘Cialis’
Tadalafil entered its phase-III clinical trial in 1999 and in 2001, the newly formed company submitted a new drug application with the US Food and Drug Administration (FDA). The branding of Cialis, which is not as influential as that of Viagra but still has a weightage, was finalized around this time.
FDA Approval
Approval of Cialis was pending for a reasonably long time as the US Food and Drug Administration (FDA) was not too convinced about the safety and efficacy of this medicine. Reports of the phase III clinical trial showed that this medicine can remain effective for up to 36 hours. These reports were officially published at the 97th meeting of the American Urological Association.
Cialis became commercially available on the European market in February 2003 after it was approved by the European Committee Propriety Medicinal Products in November 2002. Finally in November 2003, the FDA sanctioned Cialis as a reliable and effective erectile dysfunction pill.
Cialis dosage
Dosage is one of the most unique things about Cialis. Once you take a 10mg or a 20mg pill, you can have sex anytime within the next 36 hours. It means that the erection-inducing effect of tadalafil can last almost 9 times longer than that of sildenafil and nearly 7 times longer than that of vardenafil. This is one of the main reasons Cialis has been giving Viagra and other impotence pills a tough run for their money.
You need to take a Cialis pill with a glass of water 30-60 minutes before sex, preferably with a light meal. Try not to consume too much of alcohol before taking Cialis, as alcohol can reduce the effects of the medicine and can also make you physically disoriented to enjoy sexual activities. Avoid a fatty meal before taking any PDE-5 inhibitor medicine. Take only 1 pill within any given 24-hour time frame and in case you overdose accidentally and experience any discomfort, call your doctor right away.
Online availability
The immense popularity of Cialis has encouraged different clinics to sell Cialis online. Buying an erectile dysfunction medicine online is safe and confidential given that you choose a registered online clinic that offers free medical consultation and allows you to buy Cialis online only on prescription issued by a EU doctor.